TALK TO INTERVIEWER (ON/OFF lens)
This would be a doc style with juxtaposed animations, photos, graphics etc. Uncle Bill’s, your house, a school setting could work.
MOSTLY VO w/BROLL (off lens)
If the majority of the video is without seeing you until the very end we could be anywhere.
TALKING TO CAMERA (into lens)
Is this actually what you were thinking? Just note this works well for freestyle improv:
Or very brief (memorizes) segments of text, as below: